T follicular helper cell subsets: a potential key player in autoimmunity

T follicular helper cell subsets: a potential key player in autoimmunity

Blog Article

Follicular helper T (Tfh) cells are one of CD4+ lock shock and barrel art helper T subsets which promote B cell maturation, activation and antigen-specific antibody production.Autoantibodies are hallmarks of autoimmune diseases, and crucial contributions of Tfh cells in development of these diseases are now evident.Deregulation of Tfh activities can contribute to a pathogenic autoantibody production and can play an important role in the promotion of autoimmune diseases.These days multiple researchers reported three subpopulations which has distinct effector functions in Tfh cells: Tfh1, Tfh2 and Tfh17 cells.In this review, we summarize the observed alterations in whole read more Tfh cells and subset distribution during autoimmune diseases.